Skeletal muscle assessment to understand cardiometabolic interactions
نویسندگان
چکیده
Background Patients with diabetes and metabolic disorders have excess mortality after myocardial infarction (MI). Their mitochondrial function is often abnormal, and can be measured with phosphorus magnetic resonance spectroscopy (PMRS). Participation in a program of cardiac rehabilitation and secondary prevention (CRSP) reduces post-MI mortality, but typically involves only aerobic exercise and may not sufficiently improve mitochondrial function. An integrated assessment of skeletal muscle would potentially be useful to assess the impact of aerobic plus resistive exercise post-MI.
منابع مشابه
The role of clock genes in cardiometabolic disease.
The study of the circadian molecular clock in skeletal muscle is in the very early stages. Initial research has demonstrated the presence of the molecular clock in skeletal muscle and that skeletal muscle of a clock-compromised mouse, Clock mutant, exhibits significant disruption in normal expression of many genes required for adult muscle structure and metabolism. In light of the growing assoc...
متن کاملThe Role of Clock Genes in Cardiometabolic Disease Working around the clock: circadian rhythms and skeletal muscle
Zhang X, Dube TJ, Esser KA. Working around the clock: circadian rhythms and skeletal muscle. J Appl Physiol 107: 1647–1654, 2009. First published August 20, 2009; doi:10.1152/japplphysiol.00725.2009.—The study of the circadian molecular clock in skeletal muscle is in the very early stages. Initial research has demonstrated the presence of the molecular clock in skeletal muscle and that skeletal...
متن کاملUrsolic Acid Improve Skeletal Muscle Hypertrophy by Increasing of PAX7, Myod and Myogenin Expression and Satellite Cells Proliferation in Native Broiler Chickens
Ursolic acid (UA) is known as a naturally occurring triterpene pentacyclic compound in some medicinal herbs including savory that affects the skeletal muscle. In the current study, the effect of UA was evaluated on C2C12 cells and satellite cells (SCs) isolated from native broiler chicks. First in the in vitro experiment, the C2C12 cell line obtained from the Stem Cell Technology Research Cente...
متن کاملA new reduced mathematical model to simulate the action potential in end plate of skeletal muscle fibers
Usually mathematicians use Hodgkin-Huxley model or FitzHug-Nagumo model to simulate action potentials of skeletal muscle fibers. These models are electrically excitable, but skeletal muscle fibers are stimulated chemically. To investigate skeletal muscle fibers we use a model with six ordinary differential equations. This dynamical system is sensitive to initial value of some variables so it is...
متن کاملFrog Cyborg Driven by Biological Muscle Actuators That Packaged Physiological Solution
Locomotion of an animal is generated through interactions among the nervous system, the musculo-skeletal system and the environment. We particularly focus on biomachine hybrid systems in order to understand dynamics of these interactions. We can modify balances of the interactions by bio-machine hybrid systems. In this study, we intend to deal with a frog cyborg driven by biological muscles.
متن کامل